Abstract
BackgroundThis study aimed to investigate the effect of toothpaste and mouth rinse containing 0.14% zinc lactate on the reduction of three volatile oral malodor gases.Material and MethodsTen subjects with good health were recruited to take part in a crossover design study with a 7-day washout period. They were randomly assigned to use the test (toothpaste and rinse containing 0.14% zinc lactate) or placebo (negative control) treatment regimens within the two-week period. All subjects were asked to refrain from tooth brushing and eating in the morning prior to the gas collection periods. The assessment of malodor measured the quantity of three volatile sulphur compounds (VSCs) using an OralChromaTM device. Oral gas collecting was divided into four time periods; before breakfast and the morning oral hygiene practice (baseline); after oral hygiene at 30 minutes, 1 hour and 2 hours. After the baseline assessment, each subject used the test or placebo treatment regimen for 7 days. After 7 and 14 days, subjects returned to the study site to repeat the same procedures with different products. Kruskal-Wallis was used to analyze the mean differences of malodor gases between the two test regimens.ResultsThe baseline mean of total VSCs in test and control groups was 6.5±3.7 and 1.7±9.3 ng/10 ml, respectively. The percent reduction of H2S at 30 minutes, 1 hour and 2 hours was statistically significant (p<0.005) in both treatments. The percent reduction of (CH3)2S and total VSCs in both treatments after 1 hour was statistically significant (p<0.005).ConclusionsThe test treatment regimen was more effective than the placebo treatment regimen. Key words:Zinc lactate, molodor, volatile sulphur compound, mouth rinse, toothpaste.
Highlights
Oral malodor or halitosis is an important oral health problem affecting one-third of the world population [1]
This study aimed to investigate the effect of toothpaste and mouth rinse containing zinc salt or 0.4% zinc lactate on the reduction of volatile oral malodor gases compared to placebo toothpaste and mouth rinse
There was statistically significant reduction of (CH3)2S (p=0.002) and total volatile sulphur compounds (VSCs) (p=0.000) at 1 h (Table 1, Fig. 2). In this randomized, double-blinded, crossover clinical trial, treatment regimens containing 0.14 % zinc lactate showed a higher reduction of the three volatiles gases and total VSCs than the placebo treatment regimen
Summary
Oral malodor or halitosis is an important oral health problem affecting one-third of the world population [1]. Several oral care products for reducing oral malodor have been developed including toothpaste and mouth rinse containing anti-bacterial properties such as cetylpyridinium chloride (CPC) and chlorhexidine These products inhibit the mechanism of bacteria [14,15,16,17]. This study aimed to investigate the effect of toothpaste and mouth rinse containing zinc salt or 0.4% zinc lactate on the reduction of volatile oral malodor gases compared to placebo toothpaste and mouth rinse. This study aimed to investigate the effect of toothpaste and mouth rinse containing 0.14% zinc lactate on the reduction of three volatile oral malodor gases. Material and Methods: Ten subjects with good health were recruited to take part in a crossover design study with a 7-day washout period They were randomly assigned to use the test (toothpaste and rinse containing 0.14% zinc lactate) or placebo (negative control) treatment regimens within the two-week period. Conclusions: The test treatment regimen was more effective than the placebo treatment regimen
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