Clinical effect of super-selective intracoronary administration on acute myocardial infarction patients

Abstract

Objective To investigate the effect of super-selective intracoronary administration on acute myocardial in farction patients. Methods A total of 240 patients with ST-segment elevation myocardial infarction who received emergency percutaneous coronary intervention in our department from March 2012 to January 2014 were selected and divided into the intravenous drug administration group (n=77), the conventional intracoronary drug administration group (n=81) and the super-selective intracoronary drug administration group (n=82). Parameters, including the Thrombolysis in Myocardial Infarction (TIMI) classification, ST segment resolution after operation, peak values of creatine kinase MB (CK-MB) and troponin-I (cTn-I), left ventricular ejection fraction, left ventricular end-diastolic diameter (LVEDD), major adverse cardiovascular events and bleeding events, were compared between the groups. Results There were no significant differences in TIMI flow grade between the three groups (χ2=0.14, P=0.529). The percentage of patients with complete ST segment resolution after operation was higher in the super-selective intracoronary drug administration group than in the intravenous drug administration and conventional intracoronary drug administration groups (74.4% vs. 62.3%, 61.7%, χ2=8.24, P 0.05). Conclusions Super-selective intracoronary drug administration can significantly enhance cardiac function and alleviate angina pectoris in patients with acute myocardial infarction, and should be a recommended method. Key words: Myocardial infarction; Angioplasty, transluminal, percutaneus coronary; Platelet glycoprotein GPⅡb-Ⅲa complex