Clinical effect of St.John's Wort Extract on intraocular pressure in perioperative period of narrowangle glaucoma

Abstract

Objective To research the matching factor about intraocular pressure in perioperative period by studying the influence of St. John's Wort Extract to intraocular pressure during this time. Methods The 56 narrow - angle glaucoma patients were charged into St. John's Wort Extract group or control group randomly and all cases were treated with carteolol hydrochloride eyedrop by 2 times and Brinzolamide 3 times every day for lowering IOP in 3 days before operation, while the St. John S Wort Extract 300mg was given to the treatment group' s cases everyday before operation for 3 day. Control group was charged with placebo.The same score before St. John' S Wort Extract and before operation between groups was analysed by t test The IOP Of St. JohnS Wort Extract group and cintrol group 7 day. after operation was contrasted by t test and line that the cirrelation coefficient with SPSS 13.0. Results The difference of IOP between before and after the theory of St. JohnS Wort Extract were charged by t test (t =2.017 P =0.046)and the treatment group was significanly higher(8.91 ±2.73mmHg) than the control group(3.66 ± 1.93mmHg),meanwhile,1 week after operation, the IOP of treatment group(6. 37 ± 2.49mmHg)were significantly lower than control (9.25 ± 1.98),the differnece were significantly showed by t test (t = 2. 009 P =0. 041 ). In operation day, HAMA score of control gronp(13. 35 ±2.58)and treatment group(8.67 ±2.32) showed significant difference (t =2.013 P= 0.044) while HAMA score seems positive correlation to IOP in treatment group and control groups cases in operation day (r1 =0. 397 P1 =0. 046, r2 =415 P2 =0. 033). Conclusion St. John's Wort Extract seems the effect of lower IOP for glaucoma operation through modifing anxiety of narrow-angle glaucoma patients. Key words: St. John's Wort Extract; Perioperative period; Narrow-angle; Glaucoma; anxiety