Clinical effect of reduning combined with gamma globulin treatment on symptom improvement serum levels of IL-6, 25-(OH)D and LDH in children with severe mycoplasma pneumonia.

Xingna Ma,Jinyu An,Wei Gao

doi:10.12669/pjms.38.4.5203

Abstract

Objectives:To investigate the effects of Reduning combined with gamma globulin on symptom improvement and serum levels of interleukin-6 (IL-6), 25-hydroxyvitamin D[25-(OH)D] and lactate dehydrogenase (LDH) in children with severe mycoplasma pneumonia (MP).Methods:A total of 123 children with severe MP admitted to the Changzhou Cancer Hospital affiliated to Soochow University from May 2018 to April 2020 were selected as subjects and randomly divided into three groups: control Group-A, control Group-B and the observation group, with 41 cases in each group. Control Group-A was given with Reduning, control Group-B was treated with gamma globulin, while the observation group was treated with Reduning injection combined with gamma globulin. The clinical efficacy, symptom improvement, incidence of adverse reactions, serum levels of IL-6, 25-(OH)D, LDH, Toll-like receptor 4/myeloid differentiation factor 88 (TLR4/MyD88) signaling pathway and T lymphocyte subsets before and after treatment were statistically compared between the three groups.Results:The total effective rate of treatment in the observation group was higher than that in control Group-A and control Group-B (p<0.05); The time for body temperature, lung rales, and cough to return to normal in the observation group was shorter than that in control Group-A and control Group-B (p<0.05). After treatment, the observation group had lower serum levels of IL-6, LDH, and higher levels of 25-(OH)D compared with control Group-A and control Group-B (p<0.05). Moreover, the observation group had lower serum expressions of TLR4 and MyD88 (p<0.05), higher serum levels of CD4+, CD4+/CD8+, and lower CD8+ compared with control Group-A and control Group-B (p<0.05). No significant difference can be seen in the comparison of the incidence of adverse reactions between the three groups (p>0.05).Conclusions:Reduning combined with gamma globulin in the treatment of severe MP is worthy of clinical promotion and application. With such a treatment regimen, the immune function of children with severe MP can be significantly enhanced, the inflammatory response can be suppressed, and symptom improvement can be promoted, further improving the treatment outcome.

Highlights

Mycoplasma pneumonia (MP) is a common pathogen that gives rise to respiratory infectious diseases such as pediatric pneumonia[1]
Antibacterial agents have been clinically preferred for the treatment of mycoplasma pneumonia, but antibacterial agents alone have not achieved the desired effect
Gamma globulin presents a broadspectrum antibacterial and antiviral effect, which can stimulate the passive immune function of the human body, thereby alleviating the damage to the body caused by virus infection.[6]

Summary

Introduction

Mycoplasma pneumonia (MP) is a common pathogen that gives rise to respiratory infectious diseases such as pediatric pneumonia[1]. With the improvement of clinical research on the pathogenesis of MP, immunopathogenesis is believed to play a critical role in the pathogenesis of the disease.[4]. As a pure traditional Chinese medicine preparation, boasts of enhancing the body’s immune function in addition to its heatclearing, anti-inflammatory and anti-pathogen effects.[5]. Gamma globulin presents a broadspectrum antibacterial and antiviral effect, which can stimulate the passive immune function of the human body, thereby alleviating the damage to the body caused by virus infection.[6]. In this study, Reduning and gamma globulin were combined to treat severe MP, and its effects on symptoms improvement and serum levels of interleukin-6 (IL-6), 25-hydroxyvitamin D[25(OH)D] and lactate dehydrogenase (LDH) were analyzed

Objectives

Methods

Results

Conclusion