Abstract
BackgroundNon-allergic rhinopathy (NAR), formerly known as vasomotor rhinitis, is a non-allergic and non-infectious chronic disease that is accompanied by nasal hyperemia, rhinorrhea, and no increase in the number of eosinophils. Although the medications for NAR, including intranasal corticosteroids and intranasal antihistamine, have been used in clinical practice, given the relative paucity of effective therapy with available medications, alternative non-pharmacologic treatments could play an important role in treating NAR. Acupuncture treatment is representative potential alternative therapy for the treatment of various diseases, including rhinitis. Therefore, the objective of this study was to evaluate the efficacy of pricking blood at Neiyingxiang (ExHN 9) relative to acupuncture treatment at Waiyingxiang (LI 20) in patients with NAR.Methods/DesignA randomized, parallel-group, controlled, assessor single-blinded, trial will be conducted. Fifty participants with NAR will be randomized into one of two groups: either the control group with acpuncture treatment at LI 20 or the experimental group with pricking blood at ExHN 9. After randomization, a total of three sessions of treatment will be performed once a week in both groups. The total nasal symptom score (TNSS) and the Mini-Rhinoconjunctivitis Quality-of-Life Questionnaire (MiniRQLQ) at baseline and the end of the trial will be used to evaluate the efficacy of each treatment.DiscussionThis study will be the first randomized trial to evaluate the efficacy of pricking blood for the treatment of NAR. The results of this study will help establish an alternative approach for treating patients with NAR that do not respond to Western medication.Trial registrationThe trial was registered with the Clinical Research Information Service (CRiS), Republic of Korea: KCT0000195.
Highlights
Non-allergic rhinopathy (NAR), formerly known as vasomotor rhinitis, is a non-allergic and noninfectious chronic disease that is accompanied by nasal hyperemia, rhinorrhea, and no increase in the number of eosinophils
The results of this study will help establish an alternative approach for treating patients with NAR that do not respond to Western medication
A placebo-control group is a decisive tool to evaluate whether the clinical effectiveness of an intervention is truly due to the characteristic elements of an intervention [19]
Summary
A placebo-control group is a decisive tool to evaluate whether the clinical effectiveness of an intervention is truly due to the characteristic elements of an intervention [19]. The main focus of this study is to investigate the effectiveness of pricking blood at ExHN 9 in decreasing the TNSS, as a primary outcome, relative to acupuncture treatment at LI 20, which is commonly used in clinical practice and has been shown to be effective in treating patients with chronic rhinitis including NAR. This trial will provide information needed to answer relevant clinical questions regarding the efficacy of pricking blood at ExHN 9 for the treatment of NAR.
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