Clinical effect of peripheral venous total parenteral nutrition therapy for pregnant women with hyperemesis gravidarum

Abstract

Objective To investigate the clinical effects of peripheral venous total parenteral nutrition therapy for pregnant women with hyperemesis gravidarum. Methods The clinical data of 144 patients who were hospitalized for hyperemesis gravidarum in the Second Affiliated Hospital of Zhengzhou University from January 2015 to August 2018 were retrospectively analyzed. Eighty-four patients in treatment group were treated by short-term intravenous infusion of fatty milk amino acid glucose, while 60 patients in control group were treated by conventional intravenous infusion therapy. The pregnancy-unique quantification of emesis (PUQE) scores before treatment and 24, 48 and 72 hours after treatment, electrolyte correction rate 72 hours after treatment, the total hospitalization days and the time of ketone body turning negative were compared between the two groups. Results The PUQE scores of the two groups were gradually decreased 24, 48 and 72 hours after treatment. The PUQE scores of treatment group 48 and 72 hours after treatment were lower than those of control group (P=0.0012, 0.000). The effective rate of treatment group (92.85%) was better than that of control group (78.33%, P=0.0111) 72 hours after treatment. The total hospitalization days and the time of ketone body turning negative in treatment group were shorter than those in control group (P<0.01). Conclusions Peripheral venous total parenteral nutrition therapy has obvious clinical effects on hyperemesis gravidarum. It can quickly alleviate nausea and vomiting of pregnancy, which can be an promising treatment for hyperemesis gravidarum. Key words: Hyperemesis gravidarum; Pregnancy-unique quantification of emesis score; Total parenteral nutrition; Clinical effect