Clinical effect of laparoscopic colorectal cancer resection combined with liver metastases radiofrequency ablation for colorectal cancer

Abstract

Objective To investigate the clinical effect of laparoscopic resection of colorectal cancer combined with radiofrequency ablation of liver metastases for colorectal cancer. Methods Sixty patients with colorectal cancer liver metastases from Yuncheng Central Hospital from December 2015 to December 2017 were enrolled. The clinical data were retrospectively analyzed. According to the surgical plan, they were divided into two groups, with 30 cases in each group. The open group underwent open surgery, and the laparoscopic group underwent laparoscopic colorectal cancer resection combined with radiofrequency ablation of liver metastases. Perioperative related indicators, tumor markers, stress indicators, complications and survival curves were recorded and compared between the two groups. Results In the laparoscopic group, intraoperative blood loss, fever time, postoperative maximum temperature, and intestinal peristalsis recovery time were lower than those in the open group (t=12.513, 9.167, 5.293, 6.234, P<0.05). On 1, 3, and 7 days after operation, the level of motilin in the laparoscopic group was higher than that in the open group (P<0.05), and the level of interleukin-6 (IL-6) was lower than that in the open group (P<0.05). On 7 days after operation, the CD8+ level in the laparoscopic group was higher than that in the open group (P<0.05). On 3 days after operation, the cortisol level in the laparoscopic group was lower than that in the open group (P<0.05). On 1 day after operation, the blood glucose level in the laparoscopic group was lower than that in the open group (P<0.05). The proportion of laparoscopic incision infection was same to the adhesive intestinal obstruction in the laparoscopic group, both were 3.33% (1/30), lower than 23.33% (7/30) and 26.67% (8/30) in the open group. The 1-year survival rate of the laparoscopic group was 86.67% (26/30), and that of the open group was 80.00% (24/30). Log-rank analysis showed that χ2=0.473, P=0.492. Conclusion Laparoscopic surgery combined with liver metastases radiofrequency ablation for liver metastases from colorectal cancer can reduce surgical injury, with less stress response, faster postoperative recovery, fewer complications, and stable physiological function, but the 1-year survival rate of it is not obviously improved. Key words: Laparoscopic; Colorectal cancer resection; Radiofrequency ablation