Clinical effect of Haizhu-Chuanxdingi tablet with MORA-super Bio-Resonance in bronchial asthma and its influence on the levels of serum MMP-9, TIMP-1, TLR2 and ECP in patients

Abstract

Objective To explore the clinical effect of Haizhu-Chuanxiding tablet with MORA-super bio-resonance in bronchial asthma. Methods A total of 94 patients met the inclusion criteria in our hospital were divided control group and observe group by a random way, 47 in each group. The control group was treated with MORA-super bio-resonance while the treatment group with Haizhu-Chuanxiding tablet on the base of control group. The treatment time was 50 days in the 2 groups. After the treatment, the effects in the 2 groups were compared. Before and after the treatment, the levels of lung function (FVC, PEF, FEV1% and FEV1), inflammation index (hs-CRP, IL-8,TNF-α and IL-4), matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinase 1 (TIMP-1), toll like receptor 2 (TLR2) and eosinophil cationic protein (ECP) were detected in the 2 groups. Results After the treatment, the effect rate was 91.5% (43/47) in the observe group, significantly higher than 72.3% (34/47) in the control group (Z=4.201, P=0.037). After the treatment, the levels of FVC (2.45 ± 0.37 L vs. 1.93 ± 0.32 L, t=3.561), PEF(6.16 ± 1.25 L/s vs. 5.56 ± 1.10 L/s, t=3.413), FEV1/FVC (68.39% ± 6.44% vs. 62.31% ± 5.97%, t=3.315) and FEV1 (2.61 ± 0.56 L vs. 2.21 ± 0.47 L, t=3.672) in the observe group significantly higher than the control group (P<0.05). After the treatment, the levels of hs-CRP (8.14 ± 0.42 mg/L vs. 12.41 ± 0.65 mg/L, t=3.424), IL-8 (113.47 ± 11.13 ng/L vs. 153.81 ± 19.73 ng/L, t=3.692), TNF-α (0.31 ± 0.04 ng/L vs. 0.70 ± 0.13 ng/L, t=3.923)], IL-4 (39.43 ± 6.23 ng/L vs. 47.75 ± 8.23 ng/L, t=3.783) in the observe group significantly lower than the control group (P<0.05). After the treatment, the levels of MMP-9 (84.89 ± 9.19 ng/ml vs. 113.35 ± 11.35 ng/ml, t=3.671), TIMP-1 (91.53 ± 8.78 ng/ml vs. 131.15 ± 12.45 ng/ml, t=3.782), ECP (19.43 ± 1.33 ng/L vs. 25.75 ± 2.13 ng/L, t=3.561) in the observe group significantly lower than the control group (P<0.05). The level of TLR2 (270.31 ± 7.01 ng/L vs. 198.70 ± 10.13 ng/L; t=3.871, P=0.038) in the observe group significantly higher than the control group (P<0.05). Conclusions Haizhu-Chuanxiding tablet with MORA-super bio-resonance in bronchial asthma showed a good effect on patients with bronchial asthma and could promote the inflammation and lung function in patients. Key words: Asthma; Bronchi; Haizhu-Chuanxiding pian; MORA-super bio-resonance; Lung function; Cytokines; Clinical study