Abstract
目的 比较不同药物对预防长期服用小剂量阿司匹林患者胃黏膜损伤的临床疗效.方法 107例长期服用小剂量阿司匹林患者,随机分为对照组、法莫替丁组、铝碳酸镁组、奥美拉唑组和埃索美拉唑组,对照组单独应用阿司匹林治疗,其余各治疗组在应用阿司匹林治疗的基础上,分别加服法莫替丁20 mg 2次/d;铝碳酸镁500 mg 3次/d;奥美拉唑20 mg 1次/d和埃索美拉唑20 mg 1次/d治疗.3个月后,对各组患者上消化道症状及胃黏膜损伤发生率进行比较.结果 各治疗组与对照组相比,上消化道症状及胃黏膜损伤的发生率明显减少,差异有统计学意义(P<0.05);其中埃索美拉唑组发生率明显低于其余各治疗组,差异有统计学意义(P<0.05).结论 埃索美拉唑对预防长期应用小剂量阿司匹林引起的胃黏膜损伤有显著疗效。
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