Abstract
Studies have shown that COX-2 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori-induced inflammation, suggesting that cyclooxygenase-2 (COX-2) may play an important role in gastric carcinogenesis. We attempted to investigate the role of clarithromycin with tinidazole on Helicobacter pylori-related gastritis from the aspects of clinical effect and COX-2 expression. From January 2016 to January 2019, 130 patients with Helicobacter pylori-related chronic gastritis were collected and grouped into the observation group (OG) and the control group (CG). Altogether, 80 patients in the OG were treated with clarithromycin with tinidazole, while 50 patients in the CG were treated with amoxicillin with metronidazole. Clinical symptom improvement time, content of COX-2 and B cell lymphoma-2 (BCL-2), content of inflammatory factors interleukin-1 (IL-1), IL-4, and C-reactive protein (CRP), expression level of nutritional indicators serum albumin (ALB), realbumin (PA), and transferrin (TF), clearance of Helicobacter pylori, total effective rate, and incidence of adverse reactions were detected. Compared with the CG, the OG had shorter clinical symptom improvement time, lower COX-2 and Bcl-2, lower expression of inflammatory factors IL-1, IL-4, and CRP, higher expression of nutritional indicators ALB, TF, and PA, higher clearance rate of Helicobacter pylori, higher total effective rate, and lower incidence of adverse reactions. Clarithromycin combined with tinidazole can effectively improve the clinical effect of Helicobacter pylori-related gastritis and reduce the expression level of COX-2.
Highlights
Helicobacter pylori, a gram-negative bacterium, exists in the stomach, and its infection rate is as high as 90% all over the world, and about 20%-30% of infected people will undergo some kinds of diseases, including peptic ulcer, gastric carcinoma, or mucosa-related lymphoid tissue lymphoma [1,2,3]
Studies have shown that COX-2 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori-induced inflammation, suggesting that COX-2 may play an important role in gastric carcinogenesis [8, 9]
We studied the effect of clarithromycin and tinidazole on C gastritis
Summary
Helicobacter pylori, a gram-negative bacterium, exists in the stomach, and its infection rate is as high as 90% all over the world, and about 20%-30% of infected people will undergo some kinds of diseases, including peptic ulcer, gastric carcinoma, or mucosa-related lymphoid tissue lymphoma [1,2,3]. Tinidazole is a relatively new nitroimidazole derivative, which has strong antibacterial activity, good pharmacokinetic characteristics, and less side effects and is a good antibacterial drug [13]. Because of their good antibacterial properties, these two drugs are often used alone or in combination in various bacterial diseases [14,15,16]. We studied the combination of two drugs and its influence on COX-2
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