Clinical Effect of Atomized Budesonide and Terbutaline Inhalation for Acute Attack of Pediatric Asthma

Abstract

The research aimed to explore the clinical effect of atomized budesonide and terbutaline inhalation for acute pediatric asthma. Ninety children with mild or moderate asthma treated in our hospital from January 2019 to December 2019 were selected as study subjects and divided into observation group and control group according using random number table, with 45 patients in each group. On acute attack of asthma, both groups received treatments of fluid rehydration, oxygen inhalation, anti-infection, oral smooth asthma drugs, etc. Both groups were treated with atomized inhalation of budesonide, with the observation group treated with extra atomized inhalation of terbutaline. The therapy lasted for continuous 7 d. The inflammatory factor levels, stress response, lung function and clinical efficacy were compared between the two groups. Forced expiratory volume 1 percentage, peak expiratory flow percentage and forced vital capacity percentage were significantly increased both in control and observation groups (p<0.05). After treatment, both groups showed lower levels of serum nitric oxide and endothelin and higher levels of serum superoxide dismutase than before, with statistically significant differences (p<0.05). There was no significant difference in serum superoxide dismutase, nitric oxide and endothelin levels between the two groups after treatment. Observation group showed no significant differences in the duration of dyspnea, cough and lung rale and hospital stay with control group after treatment (p>0.05). The serum levels of interleukin-6, interleukin-8 and tumor necrosis factor decreased significantly in both groups (p<0.05) with significantly lower levels in observation group than in control group (p<0.05). The total effective rate of observation group was significantly higher than that of control group with significant difference (p<0.05). The treatment of budesonide combined with terbutaline for acute attacks of asthma can significantly improve patients’ lung function, relieve clinical symptoms, reduce inflammation level and ultimately improve the treatment effect, which is worth clinical promotion and application.