Clinical effect observation of nicardipine on cerebral vasospasm after subarachnoid hemorrhage

Abstract

Objective To explore the clinical effect of nicardipine on cerebral vasospasm after subarachnoid hemorrhage. Methods A total of 128 patients with cerebral vasospasm after subarachnoid hemorrhage in our hospital were enrolled from January 2013 to December 2016, and were randomly divided into two groups (control group and observation group), 64 cases in each group. The patients of the control group were given dehydration, sedation, hemostasis, neurological protection, and other symptomatic treatment, and the patients of the observation group were given intravenous infusion of nicardipine injection. And compared the clinical efficacy, clinical symptom remission rate, and cerebral vasospasm rate in both groups. Results The total effective rate of clinical treatment of the observation group was significantly higher than that of the control group (85.9% vs.68.8%), with statistically significant difference (P<0.05). After treatment, the remission rate of clinical symptoms such as headache and vomiting, cerebrospinal fluid change, meningeal irritation of the observation group were significantly higher than those of the control group, with statistically significant differences (P<0.05). The incidence of cerebral vasospasm of the observation group was significantly lower than that of the control group, with statistically significant difference (P<0.05). Conclusion Nicardipine has a good clinical effect on cerebral vasospasm after subarachnoid hemorrhage, which not only can improve clinical symptoms, but also can significantly relieve cerebral vasospasm, worthy of reference. Key words: Subarachnoid hemorrhage; Nicardipine; Cerebral vasospasm; Clinical effect