Clinical Effect and Adverse Reactions of Modified Electroconvulsive Therapy for Refractory Obsessive-Compulsive Disorder

Abstract

To explore the clinical effect and adverse reactions of modified electroconvulsive therapy for refractory obsessive-compulsive disorder. 76 patients with refractory obsessive-compulsive disorder admitted to our hospital from June 2019 to February 2021 were selected and randomly divide into two groups, with 38 cases in each group. The control group was treated with conventional drug treatment and the study group was treated with modified electroconvulsive therapy on the basis of the control group. Follow-up was given every 6 w for a total of 12 w and corresponding evaluation was given every follow-up. The total effective rate of the study group was 92.11 %, which was significantly higher than that of the control group (78.95 %) and the difference was statistically significant (p<0.05). There was no significant difference in Yale-brown obsessive compulsive scale, Hamilton anxiety scale, Hamilton depression scale, Montreal cognitive assessment scale and Tang danlin scores between the two groups before treatment (p>0.05). At the 6th and 12th w after treatment, it increased with time compared with that before treatment, The scores of Yale-brown obsessive compulsive scale, Hamilton depression scale and Hamilton anxiety scale decreased gradually. The difference was statistically significant (p<0.05). The scores of Yale-brown obsessive compulsive scale, Hamilton anxiety scale and Hamilton depression scale in the study group were significantly lower than those in the control group at the 6th and 12th w. The difference was statistically significant (p<0.05), while the Montreal cognitive assessment scale scores and Tang danlin scores of patients in the study group were significantly higher than those in the control group at the 6th and 12th w after treatment than before treatment and the difference was statistically significant (p<0.05). The incidence of near memory impairment in the study group was significantly higher than that in the control group (p<0.05), but there was no significant difference in adverse reactions such as agitation, blurred vision, constipation and abnormal examination items (p>0.05). Modified electroconvulsive therapy for refractory obsessive-compulsive disorder has good clinical effect, low adverse reactions and can effectively improve patient’s anxiety, depression and obsessive-compulsive symptoms, and improve patient’s quality of life and cognitive function. However, there is a high incidence of near memory impairment.