Clinical dynamics of anhedonia symptom in mood disorder and in alcohol use disorder

Abstract

IntroductionAnhedonia is an important transdiagnostic phenotypic characteristic of schizophrenia, mood disorders (MD), alcohol use disorder (AUD) and other mental diseases. This Symptom could reflect the neurochemical abnormalities in addictive and affective disorders when the function of reward system is dysregulated (Koob G.F., 2017).ObjectivesTo compare the severity of Anhedonia in clinic of MD and AUD in dynamic of antidepressant therapyMethods The study enrolled 93 patients under treatment in MHRI Clinics: 45 AUD (F10.2; ICD-10) and 48 MD patients (F31-F34; ICD-10). The evaluation of Anhedonia was provided with the SHAPS modified for clinician administration (SHAPS-C) (Rezvan A., 2014).ResultsDue to statistical analysis, we found the level of anhedonia in the MD group was higher than in the AUD group before the treatment. After four weeks of antidepressant therapy the scrutiny of score difference shows less changes in severity of the Symptom in the AUD group (Table 1) Table 1. Dynamics of Anhedonia in MD and AUD groups by SHAPS-C GroupTotal score upon admissionTotal score after four weeks therapyTotal score upon admission and after four weeks therapyAUD (n=45)24 (22; 27,5)22 (20,25; 28)1 (-3; 4)MD (n=48)30 (23; 38)25 (20; 28)4 (1; 8)р (Mann-Whitney test)0,0030,3730,002ConclusionsAnhedonia in the structure of AUD is less pronounced than in MD, but responds less to antidepressant therapy. The study is supported by RSF Grant no. 19-15-00023 “Clinical features and search of potential biomarkers of comorbidity of alcoholism and affective disorders”.