Abstract
Aim. To determine the significance of the study of neopterin as a marker of the endo-genetic toxicity syndrome in patients with myocardial infarction on the background of chronic obstructive pulmonary disease. Materials and methods. 64 patients with cardiovascular and respiratory pathology and 29 somatically healthy individuals of the Astrakhan region as the con-controlling group were examined. Patients were divided into 3 groups: the first 20 patients with myocardial infarction, the second group – 21 patients with chronic obstructive pulmonary disease and the third 23 patients with a combination of these diseases. Results. In patients with chronic obstructive pulmonary disease in combination with infarction of myocardium revealed the highest values of neopterin in blood serum in comparison with patients with monoiodotyrosine and somatically healthy individuals. Comparison of the values of neopterin with a number of recognized clinical and laboratory markers of endogenous intoxication revealed a positive correlation with heart rate, lactic acid, leukocyte index of intoxication and the ratio of neutrophils/leukocytes. Conclusion. In the course of the study, the clinical diagnostic value of the study of neopterin as a marker of endogenous intoxication in patients in Parkton myocardial on the background of chronic obstructive pulmonary disease has been proved.
Highlights
Patients were divided into 3 groups: the first patients with myocardial infarction, the second group – patients with chronic obstructive pulmonary disease and the third 23 patients with a combination of these diseases
In patients with chronic obstructive pulmonary disease in combination with infarction of myocardium revealed the highest values of neopterin in blood serum in comparison with patients with monoiodotyrosine and somatically healthy individuals
Comparison of the values of neopterin with a number of recognized clinical and laboratory markers of endogenous intoxication revealed a positive correlation with heart rate, lactic acid, leukocyte index of intoxication and the ratio of neutrophils/leukocytes
Summary
Определить значимость исследования неоптерина как маркера синдрома эндогенной интоксикации у больных инфарктом миокарда на фоне хронической обструктивной болезни легких. Больные были разделены на 3 группы: первая – больных инфарктом миокарда, вторая группа – больной с хронической обструктивной болезнью легких и третья – 23 пациента с сочетанием этих заболеваний. У больных хронической обструктивной болезнью в сочетании с инфарктом миокарда выявлены наиболее высокие значения неоптерина в сыворотке крови по сравнению с пациентами с мононозологиями и соматически здоровыми лицами. При сопоставлении полученных значений неоптерина с рядом общепризнанных клинико-лабораторных маркеров эндогенной интоксикации выявлена положительная корреляционная зависимость с частотой пульса, молочной кислотой, лейкоцитарным индексом интоксикации и коэффициентом нейтрофилы/ лейкоциты. В ходе исследования была доказана клинико-диагностическая ценность исследования неоптерина как маркера синдрома эндогенной интоксикации у больных инфарктом миокарда на фоне хронической обструктивной болезни легких. Клинико-диагностическое исследование неоптерина при инфаркте миокарда на фоне хронической обструктивной болезни легких.
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