Abstract
ABSTRACTA 23-month-old Holstein cow had a multi-cystic and enlarged left ovary detected by rectal palpation and ultrasonography. The plasma anti-Müllerian hormone (AMH) concentration was 36.5 ng/ml, which is higher than normal. From the clinical history and plasma AMH levels, a granulosa cell tumour (GCT) was diagnosed. Affected ovary was removed by ovariectomy, and GCT was confirmed with histopathological findings. The cow was artificially inseminated at 145 days after ovariectomy, and conceived. The plasma AMH concentration declined at 224 days after removal of affected ovary to less than 0.1 ng/ml, and recovery of fertility was achieved. In conclusion, measurement of plasma AMH levels combined with rectal palpation and ultrasonography examinations could be useful in clinical diagnosis of bovine GCT.
Highlights
Granulosa cell tumours (GCTs) are the most common ovarian tumours in cattle (Kumamoto et al 1998; Perez-Martinez et al 2004)
Proper diagnosis of GCTs might be difficult in the field-level examinations, such as rectal palpation and ultrasonography (Zulu et al 2000; Masseau et al 2004; Meganck et al 2010; Kitahara et al 2012)
This report provides the information on clinical diagnosis of GCTs based on measurement of plasma anti-Müllerian hormone (AMH) concentrations before surgical extraction of affected ovary, and the artificial insemination (AI) afterwards resulted in the cow pregnancy
Summary
Granulosa cell tumours (GCTs) are the most common ovarian tumours in cattle (Kumamoto et al 1998; Perez-Martinez et al 2004). Proper diagnosis of GCTs might be difficult in the field-level examinations, such as rectal palpation and ultrasonography (Zulu et al 2000; Masseau et al 2004; Meganck et al 2010; Kitahara et al 2012). The elevation of plasma inhibin (INH) concentration has been used an indicator for the diagnosis of GCTs (Inokuma et al 2006). In cattle, the measurement of plasma AMH concentration was identified as a more reliable and sensitive method to diagnose GCTs than that of the measurement of INH or ovarian steroids (Kitahara et al 2012). This report provides the information on clinical diagnosis of GCTs based on measurement of plasma AMH concentrations before surgical extraction of affected ovary, and the artificial insemination (AI) afterwards resulted in the cow pregnancy
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