Clinical diagnosis and treatment of autoimmune encephalitis

Abstract

Objective To analyze and study the clinical diagnosis and treatment of autoimmune encephalitis, in order to provide new ideas and theoretical support for clinical diagnosis and treatment of autoimmune encephalitis. Methods Ninety-six patients with autoimmune encephalitis were divided into anti VGKC encephalitis group, anti NMDA encephalitis group and edge leaf encephalitis group according to the different types of diseases, with 32 patients in each group. The cerebrospinal fluid, clinical features, gender and related auxiliary examination of the three groups were analyzed retrospectively. Results There was significant difference in the differential diagnosis result of immune tumor, MRI, cerebrospinal fluid, related auxiliary examination, clinical features and gender between the anti NMDA encephalitis group and anti VGKC encephalitis group. The related diseases such as non vasculitis, autoimmune meningitis, Hashimoto’s encephalopathy and metabolic encephalitis had the symptoms of disturbance of consciousness and drowsiness. Non vasculitis autoimmune disease of the brain, Hashimoto’s encephalopathy, and metabolic encephalitis and psychosis MRI test were normal. Non vasculitis autoimmune meningitis, Hashimoto encephalopathy, metabolic encephalitis, progressive multifocal white matter encephalopathy, Alzheimer’s disease, Wer-nicke-Korsakoff’s disease cerebrospinal fluid examination were normal; Progressive multifocal leukoencephalopathy, Hashimoto’s encephalopathy, metabolic encephalitis, herpes simplex encephalitis and Creutzfeldt-Jacob brucellosis could be checked by the diagnosis of clear. Conclusions There are many kinds of autoimmune encephalitis diseases, which should be diagnosed and identified according to the clinical characteristics of the patients and the implementation of targeted treatment measures. Key words: Autoimmune encephalitis; Anti VGKC encephalitis; Anti NMDA encephalitis; Limbic encephalitis