Abstract
小细胞肺癌(small cell lung cancer, SCLC)约占肺癌的15%,恶性程度高,侵袭性强,尽管其对放化疗比较敏感,但极易发生耐药,复发率高,后期治疗效果欠佳。近年来,免疫抑制剂展现了良好的抗肿瘤活性,特别是程序性死亡受体-1/配体-L1(programmed death receptor-1/ligand-L1, PD-1/L1)和细胞毒性T淋巴细胞相关抗原-4(cytotoxic T-lymphocyte-associated antigen 4, CTLA-4)检查点抑制剂的问世改变了肿瘤治疗的格局,同时SCLC具有高免疫源性,高突变负荷等免疫利好因素,免疫检查点抑制剂有望成为该领域治疗的重要突破口,本文将对SCLC免疫治疗的临床研究进展做简要综述。
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