Clinical Decision Support Systems to Predict Drug-Drug Interaction Using Multilabel Long Short-Term Memory with an Autoencoder.

Abstract

Big Data analytics is a technique for researching huge and varied datasets and it is designed to uncover hidden patterns, trends, and correlations, and therefore, it can be applied for making superior decisions in healthcare. Drug-drug interactions (DDIs) are a main concern in drug discovery. The main role of precise forecasting of DDIs is to increase safety potential, particularly, in drug research when multiple drugs are co-prescribed. Prevailing conventional method machine learning (ML) approaches mainly depend on handcraft features and lack generalization. Today, deep learning (DL) techniques that automatically study drug features from drug-related networks or molecular graphs have enhanced the capability of computing approaches for forecasting unknown DDIs. Therefore, in this study, we develop a sparrow search optimization with deep learning-based DDI prediction (SSODL-DDIP) technique for healthcare decision making in big data environments. The presented SSODL-DDIP technique identifies the relationship and properties of the drugs from various sources to make predictions. In addition, a multilabel long short-term memory with an autoencoder (MLSTM-AE) model is employed for the DDI prediction process. Moreover, a lexicon-based approach is involved in determining the severity of interactions among the DDIs. To improve the prediction outcomes of the MLSTM-AE model, the SSO algorithm is adopted in this work. To assure better performance of the SSODL-DDIP technique, a wide range of simulations are performed. The experimental results show the promising performance of the SSODL-DDIP technique over recent state-of-the-art algorithms.