Clinical curative effects of local injection of recombinant oncolytic adenovirus type 5 combined with radiochemotherapy in the treatment of advanced nasopharyngeal carcinoma

Abstract

Objective To assess the clinical curative effects of local injection of recombinant oncolytic adenovirus type 5 combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma. Methods A total of 42 patients who had been definitely diagnosed as advanced nasopharyngeal carcinoma were recruited between 2010 and 2012 from general hospital of PLA. All inpatients were divided into two groups: group A with 22 patients, who were willing to treat the cancer by local injection of recombinant oncolytic adenovirus type 5 combined with radiochemotherapy; group B with 20 patients, who were willing to treat the cancer by radiochemotherapy. The dose and method of radiochemotherapy were same in both groups. The data of follow-up investigation were statistically analyzed. Results There were no significant differences in tumor size(P=0.673)between the two groups before treatment. The tumor shrinkage rate of group A was greater than that of group B after one month treatment, and the difference was statistically significant (P=0.034). Besides, there were no significant differences in side effects(P>0.05)between the two groups. Conclusion The recombinant oncolytic adenovirus type 5 injection treatment combined with radiochemotherapy obviously enhanced the curative effect and reduced the side effects when it was applied through local injection method in treating advanced nasopharyngeal carcinoma, which opens up a new way of effective treatment of advanced nasopharyngeal carcinoma. Key words: Nasopharyngeal neoplasms; Injections; Recombinant oncolytic Adenoviridae; Radiotherapy