Abstract
Laryngeal papillomatosis (LP) can have various clinical courses. Malignant transformation is rare. The purpose of the present study was to correlate the clinical course of the disease with the histopathologic findings of the surgically removed papillomas. In the series of 123 patients, abnormal or atypical epithelial hyperplasia of the papillomas removed at the first surgical procedure appeared to be the most frequent histopathologic finding associated with the recurrent disease. Malignant transformation was detected in three patients with adult type of recurrent LP. Laryngeal carcinoma appeared five times more often in the adult patients with atypical hyperplasia than in the adults without it.
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