Abstract
Summary. Soluble forms of differentiation membrane molecules in immune cells are involved in pathogenesis of respiratory diseases. In this study, we investigated serum soluble forms of CD50, CD54, CD38, CD25, CD8, CD95, HLA I, and HLA-DR molecules in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Serum markers of activation of the immune cells (sCD25, sCD8 and sCD38), adhesion molecules (sCD50 and sCD54), apoptosis inhibitor (sCD95), sHLA I, and sHLA-DR were decreased in severe COPD. Relationships were found between the tested molecule concentrations and the lung function parameters. Long-term smoking was found to effect on the immune response of patients with COPD.
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