Clinical course of asthma in 4 cases of coronavirus disease 2019 infection

Abstract

Since the first case of severe acute respiratory syndrome coronavirus 2 infection on January 22, 2020, the number of positive cases and deaths has rapidly increased.1Centers for Disease Control and PreventionCases in the U.S.https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.htmlDate accessed: March 31, 2020Google Scholar The initial report of 140 hospitalized patients infected with coronavirus disease 2019 (COVID-19) from Wuhan, China, indicated that allergic diseases, asthma, and chronic obstructive pulmonary diseases were not risk factors for severe acute respiratory syndrome coronavirus 2 infection.2Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China [e-pub ahead of print]. Allergy. https://doi.org/10.1111/all.14238, accessed March 31, 2020.Google Scholar However, the clinical features of this condition with cough and shortness of breath (SOB) might mask, or mimic, an asthma exacerbation.3Paules CI, Marston HD, Fauci AS. Coronavirus infections—more than just the common cold [e-pub ahead of print]. JAMA. https://doi.org/10.1001/jama.2020.0757, accessed March 31, 2020.Google Scholar Given the evolving nature of this pandemic, the initial summary may not represent the clinical course of patients with asthma in other parts of the world. In this case series, we summarize the clinical course of 4 patients with asthma and COVID-19 infection presenting in the first month of the pandemic in Chicago, Illinois (Table 1). All these individuals were established patients with an academic allergy and immunology clinic and had controlled asthma at baseline.Table 1Clinical Characteristics of CasesCase no. 1Case no. 2Case no. 3Case no. 4Age34314655RaceAfrican AmericanAfrican AmericanAfrican AmericanAfrican AmericanSexFemaleFemaleFemaleMaleBMI43.629.241.331.1Age of asthma symptom onsetChildhood,Intubated as a childChildhoodChildhoodChildhoodAge of asthma diagnosis (y)21ChildhoodChildhood30Allergic comorbidities: Allergic rhinitisAllergic rhinitisAllergic rhinitisAllergic rhinitisAllergic rhinitis Chronic rhinosinusitis–––– Atopic dermatitis–––– Food allergy–Food allergyFood allergy–Health comorbidities: Sleep apneaSuspected (had PSG scheduled on the weekend of admission)NegativeNegativePositiveAllergic sensitivitiesTree, dust mite, dog, cockroachTree, grass, moldTree, grass, mold, dust miteTree, grass, mold, dust mite, catController baseline regimen: ICS/LABA (mcg)200 Fluticasone furoate/50 vilanterolBudesonide/formoterolBudesonide/formoterol200 Fluticasone furoate/50 vilanterol LTRAMontelukastMontelukastMontelukastMontelukast BiologicOmalizumab––OmalizumabBaseline prebronchodilator FEV199%95%89%85%PEFR baseline400370410350PEFR on day of ED visit (L/min)Not measured230290260Smoking status TobaccoFormer (15 pack history, quit 5 y ago)Never smokedNever smokedFormer (20 pack history, quit 7 y ago)Oxygen saturation (at the peak of symptoms)88%100%85%94%Presenting symptoms Fever (Tmax [°F])Yes (104)NoYes (103)Yes (102.7) CoughYesYesYesYes SOBYesYesYesYes WheezingYesYesYesYes ArthralgiaYesYesYesYes Physical limitationYesYesYesYes AnosmiaYesYesNoNo DiarrheaYesNoYesYesClinical course: Activity limitation21 days23 days25 days23 days Level of careED + hospitalizationEDED + hospitalizationFrequent home nurse visitsLaboratory findings: WBC (4.0-10.0 K/mcL)3.81 (low)9.63 Lymphocytes (1-4 K/mcL)1.30.930 (low) AST (0-40 U/L)42 (high)51 (high) ALT (3-44 U/L)4925 Creatinine (0.65-1.1 mg/dL)1.16 (high)1.14 (high) CRP (less than 0.5 mg/L)6.169 (high) LDH (100-190 U/L)196 (high)389 (high)Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, C-reactive protein; ED, emergency department; FEV1, forced expiratory volume in 1 second; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; LDH, lactate dehydrogenase; LTRA, leukotriene receptor antagonist; PSG, polysomnography; SOB, shortness of breath; WBC, white blood cell count. Open table in a new tab Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, C-reactive protein; ED, emergency department; FEV1, forced expiratory volume in 1 second; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist; LDH, lactate dehydrogenase; LTRA, leukotriene receptor antagonist; PSG, polysomnography; SOB, shortness of breath; WBC, white blood cell count. A 34-year-old woman with allergic rhinitis and severe persistent asthma presented to the emergency department (ED) with a 1-week history of wheezing, SOB, productive cough, new onset anosmia, myalgia, and fever with a temperature maximum of 104°F. Her peak expiratory flow rate 12 days before presentation was at baseline of 400 L/minute, and 10 days before, she was examined by her pulmonologist who documented that the patient's asthma was controlled. On day 3 of symptom presentation, she was screened through telephone, referred to a testing site, and tested for COVID-19 infection. The patient increased her use of metered-dose inhaler and nebulized albuterol without relief over the next few days. On day 6, she was feeling better. However, by day 7, her SOB worsened which prompted her to seek medical attention. In the ED, she was in hypoxemia, had sinus tachycardia (heart rate of 129 beats per minute), and was audibly wheezing. Chest X-ray examination revealed diffuse bilateral ground-glass attenuation. She was admitted and treated for pneumonia with levofloxacin for pneumonia and prednisone at a dose of 40 mg daily for asthma exacerbation. On day 8, her previous COVID-19 test result returned positive, and therefore her antibiotics were discontinued. When lying supine, her oxygen saturation decreased to 88% but improved to 94% with repositioning and albuterol treatment. She continued to have diffuse wheezing despite treatment until day 9, when her breathing improved and she was no longer in hypoxemia. After an uneventful night, she was discharged on day 10 with improved cough and without SOB. A 31-year-old woman with allergic rhinitis and moderate persistent asthma called the office reporting SOB and wheezing for 4 days and was treated with increased inhaled corticosteroid and long-acting beta agonist combination (ICS-LABA) dose. She called again on day 6 of her symptom presentation for sudden-onset anosmia, postnasal drip, and constant wheezing and coughing despite use of albuterol every 4 hours. A test for COVID-19 infection was ordered, and her test result was positive. On day 8, she felt slight improvement in SOB and became ambulatory, but on the following day, she experienced abrupt increase in SOB and experienced sharp chest pain with a need to go to the ED. She was treated with bronchodilators and steroids. Her chest X-ray examination result was clear, and she was discharged from the ED; however, she continued to experience pronounced wheezing, SOB with minimal exertion, need for albuterol every 4 to 6 hours, and pain in her chest for 26 days. A 46-year-old woman on allergen immunotherapy for allergic rhinitis and asthma came for her scheduled visit. She reported to have experienced increased cough for 1 week. She was advised to increase the dose of ICS/LABA, continue antihistamines and montelukast, and call if she develops further symptoms. Five days later, she called the clinic with increased SOB, diarrhea, and severe weakness for 2 days. She received positive test results for COVID-19 infection on day 7. Despite increase in her ICS/LABA dose and oral steroids, she continued to have severe cough, SOB, chest pain, and no appetite. On day 10, she was admitted to the ED with acute renal failure, hypoxemia, and lymphopenia. On day 13, she started to improve and was discharged but continued to have increased need for albuterol and significant SOB with minimal exertion for 24 days. A 55-year-old man with asthma and history of recent fractured foot for which he received home health care called his home nurse reporting fever, diarrhea, and nausea for 3 days. His symptoms increased in the subsequent days with addition of severe SOB, wheezing, body aches, loss of appetite, and uncontrolled cough despite use of albuterol every 2 hours. He was on his way to the ED but was advised to stay home owing to the increase of patients infected with COVID-19, and a nurse was sent to his home for treatment and evaluation. He was found to be in respiratory distress, which was treated with nebulized albuterol and home oxygen. A nasopharyngeal sample was taken which turned positive for COVID-19. He continued to experience fever, SOB, cough, body aches, and nausea, and remained bedridden for 3 weeks. He gradually improved after 20 days, but his cough and SOB remained to the point of needing nebulized albuterol every 4 to 6 hours for 27 days. We describe 4 patients with moderate to severe asthma who had a long COVID-19 infection course with minimum 24 days of respiratory symptoms. All cases needed ED visits, with 2 being admitted to the hospital. In all patients, the respiratory symptoms fluctuated. In 3 cases, the patients perceived improvement immediately before the peak of symptoms and their need for ED visits. All 4 patients reported symptoms of dyspnea, and general exhaustion occurred at an intensity not experienced during previous asthma exacerbations. They also noted that the duration of respiratory symptoms was much longer than that of previous asthma exacerbations. All 4 patients noted minimal improvement with recurrence within 2 hours of respiratory symptoms after albuterol use. This provides insight into potential manifestations of COVID-19 in patients with underlying asthma. Members of the Coronaviridae family that are associated with self-limiting respiratory tract infections have been linked to asthma exacerbations.4Zheng X.Y. Xu Y.J. Guan W.J. Lin L.F. Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review.Arch Virol. 2018; 163: 845-853Crossref PubMed Scopus (101) Google Scholar The effect of more virulent species of coronavirus on asthma is not well known. Initial studies from China did not find people with asthma at higher risk for severe respiratory syndrome because of COVID-19 infections.2Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China [e-pub ahead of print]. Allergy. https://doi.org/10.1111/all.14238, accessed March 31, 2020.Google Scholar Furthermore, they failed to adequately address asthma as a risk factor for severity of COVID-19 infection in their follow-up studies.4Zheng X.Y. Xu Y.J. Guan W.J. Lin L.F. Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review.Arch Virol. 2018; 163: 845-853Crossref PubMed Scopus (101) Google Scholar It is noteworthy that China has a much lower estimated prevalence of asthma than the United States, possibly because of underreporting, which can result in low power of these studies to investigate asthma as a risk factor.5Huang K. Yang T. Xu J. et al.Prevalence, risk factors, and management of asthma in China: a national cross-sectional study.Lancet. 2019; 394: 407-418Abstract Full Text Full Text PDF PubMed Scopus (251) Google Scholar Thus, these early findings may not be applicable for patients with asthma in other countries. Indeed, recent reports from the Centers for Disease Control and Prevention indicate that chronic lung disease in 18- to 49-year-old age group is the second most prevalent underlying condition and that this was driven primarily by asthma.6Garg S. Kim L. Whitaker M. et al.Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States, March 1-30, 2020.MMWR Morb Mortal Wkly Rep. 2020; 69: 458-464Crossref PubMed Scopus (0) Google Scholar In our small case series, all patients were under the age of 55 years, African American, and on an ICS/LABA at baseline. Wheezing, which is not a symptom associated with COVID-19, was present in all patients. Moreover, 2 of 4 patients who had blood work had leukopenia. Furthermore, all 4 patients had a history of allergic rhinitis to tree pollen. Tree sensitivity is another variable that may have affected their asthma status and/or response to this virus and cannot be excluded as a cause for their exacerbation. Although a previous study found limited association between atopy and COVID-19 infection, this might not be applicable to our patient population and needs to be further investigated.2Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China [e-pub ahead of print]. Allergy. https://doi.org/10.1111/all.14238, accessed March 31, 2020.Google Scholar In addition, obesity was identified in 2 of these patients who required admission indicating a possible accumulative risk. Obesity is a known risk factor for poor outcome in asthma and appears to affect their outcome in the setting of COVID-19 infection. The limitations of our study included a small sample size that was limited to a single site. This case series illustrates 4 cases of COVID-19 infection in patients with asthma. COVID-19 infection was associated with prolonged asthma exacerbation in these cases, especially in those with obesity who needed hospitalization. Our report calls for future multicenter studies on asthma during the COVID-19 pandemic.