Clinical Course and Lipid Metabolism Indicators in Patients with Chronic Heart Failure of Ischemic Genesis and Coexisting Hypothyroidism

Abstract

Cardiac diseases, especially chronic heart failure which, according to the World Health Organization, affects 1.5-2% of the global population, are the number one cause of mortality and morbidity worldwide, including Ukraine. Chronic heart failure is often accompanied by endocrine disorders, especially hypothyroidism, the diagnosis of which has increased over the past 10 years, and which facilitates the rapid progression of heart failure due to reduced metabolic processes and altered lipid metabolism.
 The objective of the research was to study clinical manifestations, lipid metabolism indicators and their relationship in patients with chronic heart failure of ischemic genesis and coexisting primary hypothyroidism.
 Materials and Methods. 73 patients with the average age of 55.92±2.66 years were examined. They were divided into 2 groups: Group I included 38 patients with chronic heart failure and coexisting hypothyroidism; Group II comprised 35 heart failure patients without hypothyroidism. The clinical course of chronic heart failure itself and chronic heart failure with coexisting hypothyroidism was studied, the patients’ quality of life was evaluated, the myocardial function was studied by means of the 6-minute walk test, the indicators of lipid profile were analyzed by determining the serum levels of total cholesterol, low-density lipoprotein cholesterol. To assess thyroid function, thyroid-stimulating hormone and thyroxine levels were determined by the electrochemiluminescence immunoassay.
 Results and Discussion. The clinical course and quality of life of patients with chronic heart failure and coexisting hypothyroidism were worse as compared to patients without hypothyroidism. The serum levels of total cholesterol, low-density lipoprotein cholesterol differed between both groups of patients (p<0.05).
 Conclusions. Blood lipid profile was more significantly impaired in the patients with chronic heart failure of ischemic genesis and coexisting primary hypothyroidism that could result in the rapid progression of chronic heart failure, a more severe clinical course, and more frequent complications. The quality of life was higher in patients with heart failure without hypothyroidism and their condition was significantly better.