Abstract
The sensory neuropeptide calcitonin gene-related peptide (CGRP) regulates inflammatory and immune responses and mediates vascular functions at sites of inflammation. In adults, CGRP levels in blood are elevated during sepsis and/or shock. In these studies, we examined their potential role in neonatal and maternal inflammatory and immune dysfunction. A total of 168 samples (86 from cord blood and 82 from neonates) were collected within 12 hours of birth. The patients' gestational ages ranged from 24 to 43 weeks and the birth weights ranged from 520 grams to 4445 grams. CGRP levels were measured by radioimmunoassay (RIA). Reverse phase-HPLC analysis of the immunoreactive CGRP present in adult and infant human blood revealed that it coelutes with synthetic CGRP, confirming that the RIA is measuring authentic CGRP in human blood.
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