Clinical Correlation between HLA-B27 and Inflammatory Marker in Case of Ankylosing Spondylitis (AS)

Abstract

Aims: The aim of the study is to establish the correlation among CRP(C reactive protein), ESR (erythrocyte sedimentation rate) and Rheumatoid factor in case of HLA-B27 positive and negative patients in comparison to healthy control. Materials and Methods: Eighty patients were selected for study in which 40 with AS 40 controls. The clinical and laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and HLA-B27 of patients were recorded. Results: The mean age of 40 patients was 31.6 ± 9.77 years. HLA-B27 was positive in 48 patients (60%) and it was found that disease activity was significantly associated with serum concentrations of CRP and ESR. In contrast, in the HLA B27- patients concentrations of ESR were significantly associated with disease activity, but not the concentrations of CRP. Conclusion: These results indicates that the known difference between HLA B27 positive and HLA B27 negative AS and suggest that the different pathogenic mechanisms involve in the two forms of AS, and the geographic regions and also the age at which the illness begins is one of the important predictors for the functional and clinical status in the disease course in Indian population.