Abstract
To analyze the clinical characteristics of re-positive discharged COVID-19 patients and find distinguishing markers. The demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, illness severities and chest CT scan results of 267 patients were collected from 1st January to 15th February 2020. COVID-19 was diagnosed by RT-PCR. Clinical symptoms and nucleic acid test results were collected during the 14 days post-hospitalization quarantine. 30 out of 267 COVID-19 patients were detected re-positive during the post-hospitalization quarantine. Re-positive patients could not be distinguished by demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, chest CT scan results or subsequent clinical symptoms. However, re-positive rate was found to be correlated to illness severity, according the Acute Physiology and Chronic Health Evaluation II (APACHE II) severity-of-disease classification system, and the confusion, urea, respiratory rate and blood pressure (CURB-65) score. Common clinical characteristics were not able to distinguish re-positive patients. However, severe and critical cases classified high according APACHE II and CURB-65 scores, were more likely to become re-positive after discharge.
Highlights
The Corona Virus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), has had a worldwide impact since its first case in 2019
267 COVID-19 patients admitted to the Central Hospital of Wuhan from January 2 to February 15, 2020 were enrolled in the present study. 30 out of 267 COVID-19 patients (Table 1) were detected ‘re-positive’ during the post-discharge quarantine
Common symptoms of hospitalized COVID-19 patients, including fever, muscle ache, fatigue, headache, cough, chest tightness, chest pain, and diarrhea were taken into consideration, and none of these clinical symptoms could account for the ‘re-positive’ outcome
Summary
The Corona Virus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), has had a worldwide impact since its first case in 2019. Previous studies have reported that some patients, after ‘recovering’ from the virus, could again test nucleic acid positive by RT-PCR2,3. The clinical data of 267 confirmed COVID-19 patients who had been discharged from the Central Hospital of Wuhan, China, has been retrospectively analysed.
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