Clinical Characteristics of TGA: Recent Update Analysis (P04.212)

Abstract

Objective: Transient global amnesia (TGA) is a rare amnestic syndrome characterized by the sudden onset of a selective anterograde and retrograde amnesia with a time course of up to 24 hours. Background we discuss clinical aspects, new imaging findings, and recent clinical-epidemiological data with regard to the phenotype, functional anatomy of TGA. Design/Methods: A total of 237 cases of TGA admitted to the SNUBH over a 8 years. The patients performed clinical & neurological evaluation, neuro-psychological test, ENG, EEG, MRI & SPECT. 226 patients underwent DWI within 24 hours & follow-up DWI on the 3 days after onset. A follow up was conducted at 3rd days, 14 days, 3 months & 1 years after symptom onset. Variables were selected according to the results of the multiple factorial analysis and concerned gender,age, precipitating events, medical history, personality and associated symptoms. Results: In our study of 237 subjects, however, women were significantly more common (67.9%). Events frequently described include sudden immersion in cold or hot water, physical exertion, emotional or psychological stress, pain, medical procedures, sexual intercourse, and Valsalva-associated manoeuvres and such events have been observed in 50-90% of documented attacks. In women, episodes are mainly associated with an emotional precipitating event (62%). In men, more frequently after a physical precipitating event (69%). Positive findings in DWI were detected in 80% patients being studied by our own MRI protocol for TGA, which was higher than literature published. SPECT have pointed out hemodynamic changes of the medial temporal lobe in 69.5%. TGA patients examined during the acute phase. A follow-up SPECT showed that the lesions usually disappeared after 12 months. Abnormality of EEG were detected in 22.2% patients. Conclusions: In TGA, according to sex precipitating and associated event was significantly different. However, similar DWI regardless sex difference, suggested similar underlying vascular pathophyisology. Disclosure: Dr. Yang has nothing to disclose. Dr. Kim has nothing to disclose.