Clinical characteristics of SARS-CoV-2 nucleic acid positive patients during infection in Shenzhen

Abstract

Objective To analyze the clinical characteristics of SARS-CoV-2 positive patients during infection, and we provide reference for clinical diagnosis and treatment. Methods The patients who visited the Special Fever Clinic in Shenzhen Longgang District People’s Hospital from January 22 to February 16, 2020 were selected as the research subjects, and the clinical manifestations of the patients during infection were analyzed retrospectively. Among them, 17 cases (positive group) were diagnosed as COVID-19, which were positive for SARS-CoV-2 nucleic acid, 74 cases (negative group) were diagnosed as non-COVID-19, which were negative for SARS-CoV-2 nucleic acid. We analyze the basic situation, clinical manifestations and drug use of the positive group before seeing a doctor, and to analyze blood routine examination, hs-CRP and imaging features between the two groups, and to do a statistical analysis. Results Among the 17 patients of SARS-CoV-2 nucleic acid testing positive, 9 cases were males, 8 females, patients with underlying diseases were 9 cases, patients with epidemic history 15 cases, patients with abnormal CT images 16 cases (94.12%), patients who had taken anti-inflammatory drugs or antipyretics before consultation 10 cases (58.83%). Regarding the comparison between the two groups, WBC, NEUT# and LYM#, all the three index differences had statistical significance ( P <0.05); the distribution of clinical manifestations at different levels WBC and imaging characteristics, both were statistically significant ( P <0.05). Conclusion Combining the epidemiological history, pre-visit medication, peripheral blood WBC, NEUT#, LYM#, and imaging features, it is helpful for clinicians to provide reference for early diagnosis of COVID-19, to achieve early diagnosis, early isolation, early treatment. 摘要：目的 分析新型冠状病毒肺炎患者发病初期临床表现特点, 为临床诊断治疗提供参考依据。 方法 选取 2020 年 1 月 22 日—2 月 16 日到深圳市龙岗区人民医院特殊发热门诊就诊患者为研究对象, 按新型冠状病毒核酸检测 结果, 阳性为 COVID-19 患者组和阴性为非 COVID-19 患者组, 分析两组基本情况、临床表现、就诊前用药、实验室检查 和影像学特征, 并进行统计学分析。 结果 COVID-19 患者组 17 例, 其中男性 9 例, 女性 8 例, 有基础疾病 9 例, 有明确 的流行病学史 15 例、CT 影像学异常 16 例 (占 94.12%), 就诊前使用过抗感染、退烧药 10 例 (占 58.83%); 两组 WBC、 NEUT#和 LYM#差异有统计学意义 ( P < 0.05); 从两组实验室检查的不同水平分布比较, 两组 WBC 和影像学特征差异有 统计学意义 ( P <0.05) 。 结论 结合流行病学史、就诊前用药情况、外周血 WBC、NEUT#、LYM#以及影像学特点有利于 为临床医师早期诊断新型冠状病毒肺炎提供参考依据, 做到早诊断、早隔离、早治疗。