Clinical characteristics of methicillin-resistant staphylococcus aureus and analysis of drug resistance

Abstract

Objective To analyze the clinical characteristics and drug resistance of methicillin-resistant staphylococcus aureus(MRSA) to guide for the reasonable clinical use of antibiotics. Methods A total of 45 strains of MRSA isolated from October 2015 to March 2016 were collected to analyze the clinical characteristics and resistance to antibiotics. Results A total of 45 MRSA strains were isolated, accounting for 48.91% of staphylococcus aureus separated. Antimicrobial resistant rates to penicillin, oxacillin was 100%. All isolates were sensitive to quinupristin-dalfopristin, linezolid, vancomycin, tigecycline, furadantin. Resistant rates for other antimicrobial agents were as follows: gentamicin(44.44%), ciprofloxacin(48.89%), levofloxacin(48.89%), moxifloxacin(48.89%), erythromycin(75.56%), clindamycin(75.56%), tetracycline(71.11%), rifampicin(44.44%), cotrimoxazole(8.89%), teicoplanin(2.22%). The strains were mainly distributed in ICU, respiratoy department, burn department. Major type of the sample where MRSA isolated were pus, suptum, secretion. Conclusions MRSA is worldwide in distribution and multiple resistant, clinical use vancomycin and teicoplanin, tigecycline and linezolid treating MRSA, meanwhile measures should be taking to stop the prevalence of MRSA. Key words: Methicillin-resistant staphylococcus aureus; Clinical characteristic; Drug resistance