Abstract
Objective To investigate the clinical characteristics of metabolically healthy obese(MHO)individuals, and to explore the risk of progression into metabolic disorders after 3 years. Methods A total of 3 943 residents in Jining City were evaluated twice from February 2012 to August 2015, and 3 766 individuals were enrolled excluding those with missing data. Of the subjects, 875 subjects were screened as metabolic normal population, which were divided into MHO(n=127), metabolically healthy overweight(MHOW, n=386), and metabolically healthy normal weight(MHNW, n=362)groups. T test, χ2 test, and logistic regression analysis were used for data analysis. Results The incidence of MHO was 11.63%(127/1 092)in obesity, and the proportion of MHO in females was higher than that in males(13.91% vs 7.82%, P 0.05). After adjustment for some factors including sex, age, fasting insulin, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, GGT, and creatinine, the risks of dyslipidemia in MHO(OR=2.193, 95%CI 1.359-3.539, P<0.05)and MHOW(OR=1.705, 95%CI 1.190-2.443, P<0.05)were significantly increased as compared with MHNW. Conclusion Compared with MHNW individuals, MHOW/MHO individuals show an obviously different clinical feature as well as with higher risks of dyslipidemia after 3 years. (Chin J Endocrinol Metab, 2018, 34: 30-33) Key words: Metabolically healthy obesity; Metabolic disorder; Diabetes; Dyslipidemia
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