Clinical characteristics of metabolically healthy obese individuals and risk analysis of progression into abnormal glucose and lipid metabolism

Abstract

Objective To investigate the clinical characteristics of metabolically healthy obese(MHO)individuals, and to explore the risk of progression into metabolic disorders after 3 years. Methods A total of 3 943 residents in Jining City were evaluated twice from February 2012 to August 2015, and 3 766 individuals were enrolled excluding those with missing data. Of the subjects, 875 subjects were screened as metabolic normal population, which were divided into MHO(n=127), metabolically healthy overweight(MHOW, n=386), and metabolically healthy normal weight(MHNW, n=362)groups. T test, χ2 test, and logistic regression analysis were used for data analysis. Results The incidence of MHO was 11.63%(127/1 092)in obesity, and the proportion of MHO in females was higher than that in males(13.91% vs 7.82%, P 0.05). After adjustment for some factors including sex, age, fasting insulin, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, GGT, and creatinine, the risks of dyslipidemia in MHO(OR=2.193, 95%CI 1.359-3.539, P<0.05)and MHOW(OR=1.705, 95%CI 1.190-2.443, P<0.05)were significantly increased as compared with MHNW. Conclusion Compared with MHNW individuals, MHOW/MHO individuals show an obviously different clinical feature as well as with higher risks of dyslipidemia after 3 years. (Chin J Endocrinol Metab, 2018, 34: 30-33) Key words: Metabolically healthy obesity; Metabolic disorder; Diabetes; Dyslipidemia