Abstract
Methicillin-resistant Staphylococcus aureus is crucial pathogen caused severe invasive infection disease. This study was conducted to find out the prevalence and antimicrobial susceptibility pat- tern of invasive Methicillin-resistant Staphylococcus aureus isolates at general hospital in the cen- tral region of Japan from July 2014 to June 2015. Methicillin-resistant Staphylococcus aureus was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. Invasive Methicillin-resistant Staphy- lococcus aureus disease was defined as isolation of bacteria from a normally sterile body site. One hundred seventy-one methicillin-resistant Staphylococcus aureus were isolated among which 95 (55.6%) were from inpatient and 76 (44.4%) were from outpatient. The age incidence of (0 - 1) years, (1 - 10) years, (11 - 40) years, (41 - 60) years and >60 years age groups were 18 (10.5%), 41 (24.0%), 15 (8.8%), 5 (2.9%), and 92 (53.8%) respectively. There was significant difference of age distribution between invasive and noninvasive disease in 0 - 1 years group and 11 - 40 years age group. Positive samples were received mostly from the pediatrics (56/32.7%), respiratory medi- cine (25/14.6%) and general medicine (25/14.6%). We also found the significant differences of department between invasive and noninvasive disease in pediatrics, dermatology, and surgery. Arbekacin, teicoplanin, and vancomycin were the most active antibiotics with 100% susceptible rates in our study. Our study revealed that erythromycin and gentamicin were more antimicrobial effective in invasive disease than in noninvasive disease significantly. Methicillin-resistant Sta- phylococcus aureus infection spreads worldwide easily and inadequate use of antibiotics contri- butes to uptake of their new antimicrobial resistance. Continuous antimicrobial surveys are need for guiding policy on the adequate use of antibiotics to reduce the morbidity and mortality. * Corresponding author.
Highlights
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common pathogenic bacteria causing skin and soft tissue infections to life-threatening systemic infection such as toxic shock syndrome (TSS) and necrotizing pneumonia [1]
We defined those isolates as methicillin-resistant Staphylococcus aureus
There was no significant difference of hospitalization between invasive and noninvasive disease
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common pathogenic bacteria causing skin and soft tissue infections to life-threatening systemic infection such as toxic shock syndrome (TSS) and necrotizing pneumonia [1]. The mortality rate of severe, invasive MRSA infections is about 20% and it has been estimated that MRSA infections are the leading cause of death by an infectious pathogen in USA [2]. Many countries report that MRSA strains account for approximately 25% - 50% of infectious Staphylococcus aureus in hospitals [4]. Multidrug-resistant strains of Staphylococcus aureus are often only susceptible to vancomycin, an antibiotic with considerably lower efficiency compared to beta-lactams. Vancomycin-resistant MRSA has been reported [8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
