Abstract
BackgroundCoronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).ObjectiveTo describe the clinical characteristics of patients with ARDS-COVID-19.Materials and methodsThis study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. We reported the analysis results of clinical and laboratory information, including blood routine tests, blood biochemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and C‐reactive protein (CRP)], thrombotic activity (D‐dimer) and serum ferritin and lactate dehydrogenase (LDH).ResultsThe levels of hemoglobin, AST, creatinine, monocyte count, monocyte %, RBC count, TLC, and platelet count were not significantly different among the groups. The lymphopenia and increased CRP, ALT, D-dimer, ferritin, and LDH were observed in patients with ARDS-COVID-19.ConclusionCOVID-19 patients with ARDS presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results revealed that CRP, D-dimer, LDH levels, and lymphopenia have a significant association with the COVID-19 severity and can be used as biomarkers to predict the disease severity.
Highlights
A novel coronavirus, coronavirus disease 2019 (COVID-19), was first recognized in Wuhan, China, in December 2019 [1,2,3]
The lymphopenia and increased C-reactive protein (CRP), ALT, D-dimer, ferritin, and lactate dehydrogenase (LDH) were observed in patients with ARDSCOVID-19
COVID-19 patients with acute respiratory distress syndrome (ARDS) presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels
Summary
A novel coronavirus, coronavirus disease 2019 (COVID-19), was first recognized in Wuhan (the capital of Hubei Province), China, in December 2019 [1,2,3]. The main routes of virus transmission between people are contact routes and respiratory droplets [4]. In this disease, most patients develop mild respiratory tract infection symptoms, with some people rapidly developed acute respiratory distress syndrome (ARDS) that requires hospitalization, respiratory support, and oxygen therapy [5]. The diagnosis, control, prevention, and treatment are very critical subjects in COVID-19. Delayed diagnosis of COVID-19 leads to a rapid spread of infection with increased risk for ARDS [8]. Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS)
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