Abstract
Purpose: The relationship between the thickness of subepithelial collagen bands (CBs) and the development of linear ulcerations (LUs) in collagenous colitis (CC) remains unclear. The aims of the present study were to compare the clinical and pathological features, including the thickness of CBs, in CC patients with and without LUs. Methods: Twenty five patients with CC diagnosed by pathological examination of biopsy specimens obtained by colonoscopy were included in this study. LUs were routinely classified into three stages to assess the healing process: mucosal tears, longitudinal ulcerations, or longitudinal ulcer scars. Eleven patients with LUs (the LU group) and 14 patients without LUs (the non-LU group) were retrospectively compared. Results: Ten patients (91%) in the LU group and seven (50%) in the non-LU group were taking lansoprazole (LPZ) (P = 0.030). Seven patients (64%) in the LU group and one (7%) in the non-LU group were taking nonsteroidal anti-inflammatory drugs (NSAIDs) (P = 0.0026). All LUs were located in the transverse or left colon. Patients in the LU group were older than those in non-LU group (P = 0.015). CBs were significantly thicker in the LU group (mean ± SD, 40 ± 21μm) than the non-LU group (20 ± 11μm) (P = 0.0040). Conclusion: Use of LPZ or NSAIDs is associated with the development of LUs in patients with CC. Thick CBs may cause the development of LUs in elderly patients with CC.
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