Abstract
Objective:This study investigated the incidence, risk factors, and clinical characteristics of Clostridium difficile-associated diarrhea (CDAD) in Chinese patients.Methods:Fecal specimens of patients with antibiotic-associated diarrhea (AAD) were collected to test C. difficile toxin A and B using enzyme-linked fluorescent assay to identify CDAD. By adopting a nested case-control design, the matched people (ratio 1:3) without AAD were included as controls.Results:Out of 56,172 inpatients, 39,882 (71.0%) used antibiotics, 470 suffered from AAD, and 93 were diagnosed with CDAD. The incidence of nosocomial CDAD was 166 per 100,000. The proportion of CDAD in AAD was 19.8%. CDAD patients presented with more severe clinical manifestations and exhibited more concurrent illness. Logistic regression analysis showed the risk factors of CDAD: advanced age, nasogastric tube-feeding, high APACHE II scores, high level of serum C-reaction protein, low level of serum albumin, severe underlining disease or comorbidity, and number of antibiotic intake. Twenty-nine patients (31.2%) were cured with vancomycin, 54 (58.1%) were cured after dual therapy of vancomycin plus metronidazole, 7 (7.5%) died of underlying diseases aggravated with CDAD, and 3 (3.2%) were transferred to other hospitals for personal reasons.Conclusion:The incidence of nosocomial CDAD in China was high. Some risk factors could predispose CDAD.
Highlights
Clostridium difficile (C. difficile)-associated diarrhea (CDAD) is a common cause of infectious diarrhea in hospitals, which usually occurs as a compli
We studied the incidence, risk factors, and clinical characteristics of Clostridium difficile-associated diarrhea (CDAD) in Chinese patients
The patients who exhibited diarrhea after being administered antibiotics for at least 3 days were selected according to the diagnostic criteria issued by Health Ministry of China,[6] which was adapted from the guideline of American College of Gastroenterology.[7]
Summary
Clostridium difficile (C. difficile)-associated diarrhea (CDAD) is a common cause of infectious diarrhea in hospitals, which usually occurs as a compli-. Yuqiang Nie, 1-4: Department of Gastroenterology, Guangzhou Digestive Diseases Center, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangdong, China. Correspondence: November 20, 2015 April 12, 2016 cation of antibiotic therapy. CDAD is becoming a growing worldwide health threat with an incidence of approximately 100 per million and a mortality of 1%–2.5% in western countries.[1] controlling the spread of this infection is urgently needed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
