Abstract
BackgroundThe clinical characteristics of patients with confirmed 2019 novel coronavirus disease (COVID-19) in Jilin Province, China were investigated.MethodsClinical, laboratory, radiology, and treatment data of 41 hospitalized patients with confirmed COVID-19 were retrospectively collected. The population was stratified by disease severity as mild, moderate, or severe, based on guidelines of the National Health and Medical Commission of China.ResultsThe 41 hospitalized patients with COVID-19 were studied, and the median age was 45 years (interquartile range [IQR], 31–53; range, 10–87 years) and 18 patients (43.9%) were female. All of the patients had recently visited Wuhan or other places (ie, Beijing, Thailand) or had Wuhan-related exposure. Common symptoms included fever (32[78%]) and cough (29[70.7%]). All patients were without hepatitis B/C virus hepatitis. CRP (C-reactive protein, 11.3 mg/L [interquartile range {IQR}, 2.45–35.2]) was elevated in 22 patients (53.7%), and cardiac troponin I (1.5 ng/mL [IQR, 0.8–5.0]) was elevated in 41 patients (100%). Chest computed tomographic scans showed bilateral ground glass opacity (GGO) or GGO with consolidation in the lungs of 27(65.9%) patients. 31(75.6%) patients had an abnormal electrocardiograph (ECG). Comparing the three groups, the levels of CRP and cardiac troponin I, GGO distribution in bilateral lungs, and electrocardiogram changes were statistically significant (p < 0.05). Cardiac troponin I had a strong positive correlation with CRP (r = 0.704, p = 0.042) and LDH (r = 0.738, p = 0.037).ConclusionSignificant differences among the groups suggest that several clinical parameters may serve as biomarkers of COVID-19 severity at hospital admission. Elevated cTnI could be considered as a predictor of severe COVID-19, reflecting the prognosis of patients with severe COVID-19. The results warrant further inspection and confirmation.
Highlights
Beginning in December 2019, a series of unexplained cases of viral pneumonia occurred in Wuhan City, Hubei province
The Coronavirus Research Group of the International Virus Classification Committee changed the name of the causative virus 2019-nCoV to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was subsequently named by the World Health Organization (WHO) as coronavirus disease 2019 (COVID-19)
We found that the low lymphocyte count and low white blood cell (WBC) count were not statistically significant among the three groups by the Kruskal-Wallis H test and Bonferroni correction(p > 0.0167) (Table 5)
Summary
Beginning in December 2019, a series of unexplained cases of viral pneumonia occurred in Wuhan City, Hubei province. During the following 2 months, the disease broke out in other part of China and internationally as well [1,2,3,4]. The Coronavirus Research Group of the International Virus Classification Committee changed the name of the causative virus 2019-nCoV to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was subsequently named by the WHO as coronavirus disease 2019 (COVID-19). Coronaviruses include SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus). SARS-CoV-2 infections in humans, with person-to-person transmission, probably began at a seafood market in Wuhan [2, 3, 5,6,7,8, 12, 13]. The clinical characteristics of patients with confirmed 2019 novel coronavirus disease (COVID-19) in Jilin Province, China were investigated
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