Clinical characteristics of 40 patients with severe fever with thrombocytopenia syndrome in Tiantai County

Abstract

Objective To investigate regional epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS). Methods A total of 40 SFTS cases in Tiantai County People's Hospital from May 2012 to May 2018 were enrolled, and were divided into survival group (33 cases) and death group (7 cases) . Epidemiology, clinical and laboratory data, treatment and prognosis were systematically reviewed and statistically analyzed. Results Of 40 SFTS patients, 14 had history of tick bites. Fever was the first symptom in all the patients, followed by muscle ache (32 cases) , nausea and vomiting (25 cases), abdominal pain and diarrhea (20 cases) , lymphadenopathy (20 cases) , hemorrhage (14 cases) , neuropsychiatric symptoms(12 cases). The complications included pulmonary infection (6 cases) , atrial fibrillation (10 cases), heart failure (12 cases). Neuropsychiatric symptom, atrial fibrillation and heart failure occurred highly in the death group (χ2 =9.532, 6.984 and 12.864, P all <0.05) . PLT, ALT, AST, LDH, CK, Ca2+, Cr, ALB, APTT, TT and plasma D dimer during the 12th to 14th day of the disease were different from the fatal cases to the survivals (Z=1.977, 3.640, 6.250, 12.850, 16.940, 2.346, 2.108, 2.432, 21.820, 24.680 and 2.970, P all<0.05) . Conclusions From 2012 to 2018, SFTS cases were distributed sporadically in Tiantai. Occurrent neuropsychiatric symptom, atrial fibrillation and heart failure may reduce the survival rate. Several indexes in SFTS critical period might forebode a critical illness and worse prognosis. Key words: Bunyaviridae infections; Clinical features; Complication; Survival rate