Abstract
Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection. This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014. Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection. All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection.
Highlights
Bien que les infections congénitales à cytomégalovirus soient la cause non génétique principale de la perte auditive neurosensorielle chez l’enfant, leur vrai impact reste inconnu
Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection
Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection
Summary
Bien que les infections congénitales à cytomégalovirus (cCMV) soient la cause non génétique principale de la perte auditive neurosensorielle chez l’enfant, leur vrai impact reste inconnu. Objectifs de l’étude: 1) Identifier le nombre d’infections cCMV symptomatiques et asymptomatiques, diagnostiquées au Centre hospitalier universitaire vaudois entre 1999 et 2014; 2) décrire le suivi auditif et neurodéveloppemental des enfants avec une infection cCMV; et 3) comparer les issues cliniques entre les enfants nés de mères primoinfectées versus non-primoinfectées. Résultats: 50 nouveau-nés ont été identifiés avec une infection cCMV; 39 (78%) étaient symptomatiques à la naissance, dont 29 (74%) avaient des symptômes neurologiques. Conclusion: Tous les enfants avec une perte auditive neurosensorielle ou un neurodéveloppement anormal étaient symptomatiques à la naissance. Des résultats de suivis auditifs et neurodevéloppementaux similaires ont été observés chez les enfants nés de mères primoinfectées et nonprimoinfectées. 17 to 20% of all neonates with symptomatic and asymptomatic cCMV infection will have an abnormal neurological outcome, mainly SNHL, cognitive delay, neuromotor impairment such as cerebral palsy and balance disturbances, seizures or visual impairment [8,9,10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
