Clinical Characteristics and Prognostic Factors for Adult HIV-Negative Burkitt Lymphoma: a Single-Center Retrospective Study.

Abstract

We performed a retrospective cohort study to examine the clinical characteristics, prognosis factors, and survival outcomes of HIV-negative adult Burkitt's lymphoma. The retrospective study was conducted on adult patients, who were diagnosed with HIV-negative Burkitt lymphoma at our center between 2014 and 2022. Univariate and multivariate Cox regression analyses were conducted to identify potential risk factors for mortality. Survival rates were estimated, using the Kaplan-Meier curve and the log-rank test. A total of 23 patients were identified, with male patients making up the majority (69.6%). Over half (56.5%) of the patients had bone marrow involvement, while a third (30.4%) had central nervous system involvement. More than half of the patients (13/23) were given R-hyper CVAD as their first-line therapy. The median PFS and OS were 11 and 12 months, respectively. In multivariate analysis, central CNS involvement was found to be an independent predictor of worse OS among patients with BL, with a hazard ratio of 15.53 (95% CI: 1.09 - 22.5). We also found that patients with CNS involvement were more likely to have higher LDH (p = 0.045) and ECOG scores (p = 0.002). Our research revealed that CNS is an important predictor of OS and DFS. LDH > 3ULN levels were associated with worse PSF. This study is valuable, because it shows the characteristics of a population that is currently poorly studied and has a lower incidence in China.