Clinical characteristics and prognostic analysis of 15 children with streptococcus pneumoniae meningitis

Abstract

Objective To summarize the clinical characteristics complications, antimicrobial resistance and prognosis in 15 children with streptococcus pneumoniae meningitis so as to improve the diagnosis and treatment of this disease. Methods A systematic retrospective analysis was carried out in the Qilu Children's Hospital of Shandong University from Jan.2010 to Jan.2013, and clinical data from 15 children with streptococcus pneumococcal meningitis were retrospectively analyzed and followed up for 6 months in order to observe the prognosis. Results Eleven cases of streptococcus pneumoniae meningitis occurred in the winter and spring.And it often occurred in children less than 2 years of age who lived in rural areas(13 cases). The clinical manifestations showed diverse characteristics, severe symptoms, obvious changes in symptoms and cerebrospinal fluid were observed.Severe or death cases had low temperature, low leukopenia or low blood platelet.Common complications of streptococcus pneumoniae meningitis included anemia (10 cases), hypoalbuminemia (9 cases), sepsis (8 cases). Multi-drug resistance and complications in streptococcus pneumoniae meningitis led to the therapeutic difficulties.In this study, 3 cases were cured, 9 cases had varying degrees of sequences, such as left languages, sports, hydrocephalus and cognitive dysfunction, and 3 cases died, and the main cause of death was multiple organ dysfunction syndrome. Conclusions Streptococcus pneumoniae meningitis mainly occurred in the winter and spring.And the children under 2 years of age who lives in rural areas were often attacked.Clinical characteristics and cerebrospinal fluid changes obviously; severe cases are common with low temperature, low leukopenia or blood platelet.And there are often diverse complications and multi-sequelae; the problem of multi-drug resistant and complications can lead to great difficulties in the clinical treatment. Key words: Streptococcus pneumoniae meningitis; Clinical characteristic; Antimicrobial resistance; Child