Abstract
Background and objectiveLittle is yet known whether pathogenesis of COVID-19 is different between young and elder patients. Our study aimed to investigate the clinical characteristics and provide predictors of mortality for young adults with severe COVID-19.MethodsA total of 77 young adults with confirmed severe COVID-19 were recruited retrospectively at Tongji Hospital. Clinical characteristics, laboratory findings, treatment and outcomes were obtained from electronic medical records. The prognostic effects of variables were analyzed using logistic regression model.ResultsIn this retrospective cohort, non-survivors showed higher incidence of dyspnea and co-existing laboratory abnormalities, compared with young survivals in severe COVID-19. Multivariate logistic regression analysis showed that lymphopenia, elevated level of d-dimer, hypersensitive cardiac troponin I (hs-CTnI) and high sensitivity C-reactive protein (hs-CRP) were independent predictors of mortality in young adults with severe COVID-19. Further analysis showed that severely young adults with two or more factors abnormalities above would be more prone to death. The similar predictive effect of above four factors had been observed in all-age patients with severe COVID-19.ConclusionLymphopenia, elevated level of d-dimer, hs-CTnI and hs-CRP predicted clinical outcomes of young adults with severe COVID-19.
Highlights
Background and objectiveLittle is yet known whether pathogenesis of COVID-19 is different between young and elder patients
It has to be noted that elderly patients were with more comorbidities, leading to more complicated pathogenesis in COVID-19 [8]
Demographics and baseline characteristic of young adults with severe COVID‐19 From 25 Jan 2020 to 15 Feb 2020, 376 patients were admitted to Tongji hospital with confirmed Coronavirus disease 2019 (COVID19), of whom 299 were considered ineligible. 77 young adults with severe COVID-19 were included in this study (Additional file 1: Figure S1)
Summary
Little is yet known whether pathogenesis of COVID-19 is different between young and elder patients. Our study aimed to investigate the clinical characteristics and provide predictors of mortality for young adults with severe COVID-19. The newly emergent human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), resulting in epidemics and pandemics [1, 2]. Accumulating studies have suggested that all ages people are susceptible to SARS-CoV-2 infection, which can result in severe and even fatal respiratory diseases [6,7,8]. It has to be noted that elderly patients were with more comorbidities, leading to more complicated pathogenesis in COVID-19 [8]. Would the pathogenesis of COVID-19 be different in young adults, with less comorbidities and more strong host immune?
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