Clinical characteristics and perinatal outcomes of non-overweight/obese pregnant women with polycystic ovary syndrome

Abstract

To determine clinical characteristics and perinatal outcomes of non-overweight/obese (pre-pregnancy body mass index BMI < 24 kg/m(2)) pregnant women with polycystic ovary syndrome (PCOS). The screening of PCOS was performed when they were at first prenatal visit in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from May, 2008 to July, 2010.61 PCOS women of pregnancy women with BMI < 24 kg/m(2) were considered as the study subjects, and 122 pregnant women without PCOS matched by age and pre-pregnancy body mass index (BMI) were selected as the control ones. Patients with history of pre-pregnancy diabetes, hypertension, cardiovascular disease, renal diseases and multiple pregnancies were excluded from the study. We followed pregnancy outcomes of two groups until delivery. Significantly higher total cholesterol, triglycerides concentrations and low-density lipoprotein cholesterol concentrations were found in the PCOS group than in the controls. PCOS women with BMI < 24 kg/m(2) had significantly higher rates of GDM (27.9% (17/61)) and pre-eclampsia (13.1% (8/61)) compared with the controls (15.6% (19/122), 1.6% (2/122)), P < 0.05, < 0.01, respectively. No statistical significance was found in prevalence of pregnancy-induced hypertension, polyhydramnios, oligohydramnios, macrosomia, premature rupture of membranes, placental abruption, macrosomia, fetal death and neonatal congenital abnormality between the two groups (all P > 0.05). It is at increased risk of GDM and pre-eclampsia in non-overweight/obese PCOS women, this risk seemed to be due to PCOS itself rather than obesity.