Clinical characteristics and outcomes of pregnancy after invasive prenatal testing in women with multiple pregnancy

Abstract

Retrospective assessment of the obstetric and gynecological history, gravidity, parity and complications of the current pregnancy in women who underwent amniocentesis (AC) and chorionic villus sampling (CVS) are presented. The features of invasive prenatal procedures (IPP), as well as the outcomes of pregnancy and childbirth were studied. The frequency of spontaneous abortion (SA) after AC was 2.90 ± 2.05%, during CVS — 2.80 ± 2.82%, in the comparison group (GC) (1.10 ± 1.07%, p > 0.017). There were no statistically significant differences in invasive prenatal diagnostics in the 1st and 2nd trimesters in multiple and single pregnancies. AC and CVS do not affect the average delivery time (CVS — 37.0 (34.0–38.0) weeks, AC — 36.0 (34.0–38.0) weeks, GS — 36.0 (34.0–37.0) weeks, p > 0.017), weight of newborns (CVH — 2440.0 (1960.0–2845.0) g, AC — 2600.0 (1850.0–2760.0) g, GS — 2325.0 (1800.0–2740.0) g, p > 0.017). IPP do not increase the preterm birth rate at 23–36 weeks' gestation (CVH — 41.40 ± 9.15%, AC — 51.60 ± 6.36%, GS — 54.40 ± 5.19%, p > 0.017) and does not increase perinatal mortality.