Clinical characteristics and outcomes of patients with reversible Splenial lesion syndrome (RESLES)

Abstract

Background: Reversible splenial lesion syndrome (RESLES) is an entity characterized by transient Magnetic Resonance Imaging (MRI) findings of the splenium of the corpus callosum (SCC), and induced by heterogeneous triggers such as infection, drugs, metabolic disorders, and others. Typically, RESLES is a benign disease course without neurological sequelae and is often called clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS), although several cases with poor outcome have also been reported. Its prognostic factors still remain to be seen.