Abstract
目的探讨原发中枢神经系统淋巴瘤(PCNSL)的临床特征、治疗方案以及预后相关因素。方法回顾性总结北京协和医院自1999年6月至2012年6月收治的37例PCNSL患者临床资料，对患者临床特征、治疗以及预后相关因素进行分析。结果全部37例PCNSL患者中位发病年龄57(17~78)岁，男女比为2.7:1。以颅内高压和智能障碍为最常见临床表现，起病至诊断中位时间1.5(1~24)个月。肿瘤累及部位以大脑半球为主，且多灶病变更为常见。36例经治患者无进展生存(PFS)时间为18.0 (95%CI 9.1~26.9)个月，总生存(OS)时间为36.0 (95%CI 21.7~50.3)个月，3年累计OS率为46.9%。放化疗联合治疗与单纯化疗组PFS时间[16.0 (95%CI 8.9~23.1)个月对26.0(95% CI 2.9~49.1)个月]及OS时间[36.0 (95%CI 2.3~69.7)个月对29.0 (95%CI 23.4~34.6)个月]比较，差异均无统计学意义(P=0.401、0.866)。结论PCNSL预后不佳，化放疗联合并不能显著改善患者生存，其最佳治疗方案应需进一步探索。
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