Clinical characteristics and outcome of hepatocellular carcinoma in children and adolescents

Abstract

Hepatocellular carcinoma (HCC) rarely occurs in children and adolescents and has been reported to be highly hepatitis B related more than 10years ago. However, after global vaccination for hepatitis B virus (HBV), the characteristics and outcome of pediatric HCC remain undefined. Patients with HCC admitted from 2004 to 2010 were retrospectively reviewed in a large tertiary hospital. 45 (1.97%) pediatric HCC were diagnosed (age≤18years), with predominantly male patients (93.3%). 32 (71.1%) children were HBV positive, 30 of whom had vertical transmission from their mothers. HBV positivity was associated with liver cirrhosis and portal vein invasion, and thus compromised survival. Advanced disease prevented surgical resection due to large tumor size (>10cm, 66.7%), early metastasis (24.4%), bilateral involvement (57.8%) and portal vein invasion (46.7%). The median survival for resectable, transarterial chemotherapy and embolization and untreated patients was 28.6, 4 and 5months, respectively (p<0.001). Patients with distal metastasis had significantly poorer survival rate than those without metastasis (p<0.001). Screening of children whose mothers are HBV carriers is important in early detection of pediatric HCC. HBV-associated HCC in pediatric patients, especially in endemic areas, should be detected earlier for more resectability and improvement of surgical prognosis.