Abstract
In this study, the clinical and immunogenetical features in a cohort of Chinese patients with BCGosis/BCGitis were investigated. For the patients with abnormal immunological functions, Sanger sequencing was used to identify the involved genes. There were 74 confirmed cases of BCGosis/BCGitis during 2007–2012. Classified by infected tissues and organs, no cases only had local infection, 39 patients had a regional infection, 21 patients had a distant infection and 14 patients had a disseminated infection. Thirty-two patients (43.2%) had definitive primary immunodeficiency diseases (PID) and chronic granulomatous disease (CGD) is the most common PID (n = 23, accounted for 71.9% of all PID patients). For CGD patients, based on the anti-tuberculosis treatment, administration of rhIFN-γ resulted in better control of BCGosis/BCGitis. The results indicate that PIDs are associated with susceptibility to BCG disease. For children with BCGosis/BCGitis, immune function evaluation is necessary, and IFN-γ treatment for BCGosis/BCGitis patients with CGD is effective.
Highlights
The Bacillus Calmette-Guerin (BCG) vaccine has existed for 80 years and is one of the most widely used of all current vaccines
There is no significant difference in the age of onset of BCGosis/BCGitis between these two groups
The BCG vaccine has existed for 80 years and is one of the most widely used of all current vaccines, reaching .80% of neonates and infants in countries where it is part of the national childhood immunization program [1]
Summary
The Bacillus Calmette-Guerin (BCG) vaccine has existed for 80 years and is one of the most widely used of all current vaccines. The BCG vaccine has a protective effect against meningitis and disseminated tuberculosis (TB) in children [1]. The World Health Organization (WHO) recommends that all infants in highly endemic countries receive a single dose of the BCG vaccine [2]. The incidence of BCG infection is approximately 1:10,000–1:1,000,000 [3]. The BCG-induced disease phenotypes were designated as local, regional, distant, or disseminated pattern based on a revised pediatric classification proposed by Hesseling et al [4]. The former two patterns were conventionally termed as BCGitis and the latter two as BCGosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
