Clinical characteristics and homology in Acinetobacter baumannii

Abstract

Objective To investigate the clinical characteristics and homology in Acinetobacter baumannii from cilinical isolates. Methods A retrospective analysis was performed on the clinical and antimicrobial sensitivity data.Identification of the clinical Acinetobacter baumannii isolates and susceptibility testing were performed using Vitek2 Compact.Genotyping and homology of 115 strains of Acinetobacter baumannii were analyzed by enterbacterial repetitive intergenic consensus (ERIC)-polymerase chain reaction(PCR). Results The mean age of the patients was (75±16) years old.The most frequent comorbidity were chronic obstructive pulmonary disease (COPD) and diabetes mellitus.72(62.61%) patients were under invasive procedure.86 (74.78%) patients used more than two antibiotics.Mechanical ventilation were used in 48(41.74%) patients.The 115 strains of Acinetobacter baumannii remained sensitive to colistin (resistance rate 0%), followed by Tygecycline (resistance rate 7.83%). The 115 strains were identified as 9 epidemic clones. Conclusions The risk factors of nosocomial infection caused by Acinetobacter baumannii included advanced age, presence of comorbidity, invasive procedures, mechanical ventilation and the use of more than two antibiotics.The strains of Acinetobacter baumannii were resistant to most of the antimicrobial agents. Key words: Acinetobacter baumannii; Enterobacterial repetitive intergenic consensus; Polymerase chain reactiont; Homology