Clinical Case of Using Intravenous Forms of Anti-Tuberculosis Drugs to Improve the Treatment Efficiency of Tuberculosis in Patients with Malabsorption Syndrome

Kuzhko Mm Butov Do,Hulchuk Nm Avramchuk Ov

doi:10.4172/2161-105x.1000269

Abstract

Clinical case of progression of pulmonary tuberculosis on a background of therapy with oral antimycobacterial drugs is presented for your information. Malabsorption of oral formulations was confirmed during treatment, allowing to change the treatment strategy and to cure the patient.

Highlights

The use of antimycobacterial therapy in its majority leads to positive dynamics of disease, sputum conversion and tuberculosis cure
Anti-tuberculosis drugs (ATD) are usually well absorbed when administered orally.the determining factor for drug absorption is the absorptive capacity of the intestinal mucosa, which may be altered in several clinical situations [1,2,3]
Clinical signs or conditions that can lead to malabsorption syndrome should be determined in patients with the absence of a “positive response” to treatment, and their combination with low concentrations of anti-tuberculosis drugs in the blood can serve as a criterion for a change of treatment

Summary

Background

The use of antimycobacterial therapy in its majority leads to positive dynamics of disease, sputum conversion and tuberculosis cure. The absence of the expected positive response to the used therapy we define in a limited number of drug-susceptible tuberculosis patients. One of the most common causes of the absence of a positive response in case of provided prescription of medicines under defined and controlled sensitivity of receiving chemotherapy may be malabsorption/ maldigestion syndrome. Pulmonary tuberculosis detected by X-ray examination (Figure 1) on complaints of cough with little amount of sputum, low-grade fever up to 37.1-37.3°C, weakness, sweating, weight loss of 12 kg within 1 year, defecation to 2−3 times a day (in big volume, foul-smelling, grey colour, with a shiny surface). As for the newly diagnosed pulmonary tuberculosis,the patient was hospitalized tothe district tuberculosis dispensary(DTD) in the place of residence

Findings upon admission to the DTD

Result

Conclusions