Abstract
Neonatal thyrotoxicosis is 1% of all cases of thyrotoxicosis in children and adolescents and it is mostly determined by the mother’s Graves’ disease. The most dangerous manifestations of neonatal thyrotoxicosis are intrauterine growth retardation, tachycardia, and heart rhythm disturbances. Timely diagnostics and beginning of treatment are of great importance due to the high risk of fatal cardiac disruption in the acute phase of the disease and its serious consequences for the body. The article presents a clinical case of a patient with neonatal thyrotoxicosis diagnosed only at the age of 1 month, despite the mother’s burdened anamnesis; it contains a plan for diagnostic search and tactics of child management.
Highlights
Neonatal thyrotoxicosis is 1% of all cases of thyrotoxicosis in children and adolescents and it is mostly determined by the mother’s Graves’ disease
The article presents a clinical case of a patient with neonatal thyrotoxicosis diagnosed only at the age of 1 month, despite the mother’s burdened anamnesis; it contains a plan for diagnostic search and tactics of child management
Значительно реже тиреотоксикоз у детей связан с активирующей мутацией гена GNAS, ведущей к образованию аномальной структуры α-субъединицы G-белка [2], мутацией генов рецепторов к тиреоидным и тиреотропному гормонам (ТТГ), передозировкой препаратов левотироксина, назначенных по поводу гипотиреоза новорожденному, йодной интоксикацией во время беременности и в период новорожденности [3]
Summary
Neonatal thyrotoxicosis is 1% of all cases of thyrotoxicosis in children and adolescents and it is mostly determined by the mother’s Graves’ disease. The article presents a clinical case of a patient with neonatal thyrotoxicosis diagnosed only at the age of 1 month, despite the mother’s burdened anamnesis; it contains a plan for diagnostic search and tactics of child management. Сообщения о риске развития неонатального тиреотоксикоза при болезни Грейвса на фоне беременности достаточно разноречивы – указывают на риск от 1 до 8%, что, вероятно, зависит от активности аутоиммунного процесса и выраженности тиреотоксикоза у принимающих участие в исследовании женщин.
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